PerspectiveBiophysics

Fine Tuning Gene Regulation

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Science  15 Feb 2013:
Vol. 339, Issue 6121, pp. 766-767
DOI: 10.1126/science.1232663

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Summary

On page 816 of this issue, Kim et al. (1) report that a DNA-bound protein can influence the properties of an adjacent protein if both are bound to the DNA strand within about 15 base pairs (bp) of each other. The authors attribute their observations to an allosteric effect, in which a distortion of the DNA strand by the first protein modulates the binding of the second protein. The observations have important implications for gene regulation.