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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Science  15 Feb 2013:
Vol. 339, Issue 6121, pp. 819-823
DOI: 10.1126/science.1231143

Article Information

vol. 339 no. 6121 819-823

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History: 
  • Received for publication October 5, 2012
  • Accepted for publication December 12, 2012

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Author Information

  1. Le Cong1,2,*,
  2. F. Ann Ran1,4,*,
  3. David Cox1,3,
  4. Shuailiang Lin1,5,
  5. Robert Barretto6,
  6. Naomi Habib1,
  7. Patrick D. Hsu1,4,
  8. Xuebing Wu7,
  9. Wenyan Jiang8,
  10. Luciano A. Marraffini8,
  11. Feng Zhang1,
  1. 1Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA, and McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  2. 2Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  5. 5School of Life Sciences, Tsinghua University, Beijing 100084, China.
  6. 6Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  7. 7Computational and Systems Biology Graduate Program and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  8. 8Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
  1. To whom correspondence should be addressed. E-mail: zhang{at}broadinstitute.org
  1. * These authors contributed equally to this work.

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