PerspectiveCell Biology

Dynamin Flexibility Drives Fission

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Science  22 Mar 2013:
Vol. 339, Issue 6126, pp. 1392-1393
DOI: 10.1126/science.1236005

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Summary

An unresolved issue in cell biology concerns the mechanisms by which lipid bilayers remodel in fission and fusion reactions in vesicular trafficking pathways. An important step in understanding comes from the report by Shnyrova et al. on page 1433 of this issue (1), which investigates the mechanism by which the dynamin guanosine triphosphatase (GTPase) catalyzes fission when bound to lipid tubes in vitro.