Technical Comments

Comment on “Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters”

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Science  19 Apr 2013:
Vol. 340, Issue 6130, pp. 273
DOI: 10.1126/science.1231895

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Conrad et al. (Reports, 10 August 2012, p. 742) reported that Drosophila dosage compensation might largely be due to increased recruitment of RNA polymerase II to promoters. A reassessment of the numerical operations revealed that the authors’ calculations are severely confounded by an inappropriate numerical procedure. A rectified analysis strongly suggests that the authors’ conclusions are not supported by their data.

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