Science Webinar Series

Advances in Protein Expression: High Throughput Tools for Improving Analysis

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Science  19 Apr 2013:
Vol. 340, Issue 6130, pp. 382
DOI: 10.1126/science.340.6130.382-c

Summary

The characterization of protein expression systems, particularly for biotherapeutics and structural biology, requires the testing of many variables to obtain the optimal clones. Assessing these variables—including expression system, cell culture, fermentation, and various media components such as growth factors—is costly and time intensive if done individually. However, high throughput analytical technologies and multi-use automation platforms can accommodate the high sample throughput necessary to provide fast, accurate, and efficient optimization of protein expression and purification conditions. This ultimately improves quality, mitigates risk, and accelerates the time to produce proteins for both research and therapeutics applications.