Systems Vaccinology

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Science  03 May 2013:
Vol. 340, Issue 6132, pp. 527
DOI: 10.1126/science.340.6132.527-a

Vaccination is a powerful approach for disease prevention, but why are some vaccines so effective whereas others fail? Obermoser et al. begin to answer this question by characterizing the immune response induced in people given either the trivalent seasonal influenza vaccine or the pneumococcal vaccine, both of which induce a protective antibody response. Gene expression profiling combined with functional assays at multiple time points after vaccination revealed that the two vaccines take different routes early, despite a similar ability to induce protective antibodies. The early response to the influenza vaccine was characterized by the induction of an antiviral and, to a lesser extent, inflammatory gene response. In contrast, the pneumococcal vaccine elicited a predominately inflammatory gene signature. By day 7 after vaccination, a developing antibody response was apparent in all vaccines. The figures are available in an interactive format, where readers can access the vast amounts of underlying data, providing an important resource for the vaccine community.

Immunity 38, 831 (2013).

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