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Science  03 May 2013:
Vol. 340, Issue 6132, pp. 643
DOI: 10.1126/science.340.6132.643-a


The new Mastercycler nexus X1 is the latest addition to the Mastercycler range of polymerase chain reaction (PCR) instruments. It provides researchers with increased heating and cooling rates by uniting the innovative software found in the Mastercycler nexus with a fast 96-well block. All this is achieved while maintaining low power consumption and low noise emission levels (蠅 40 dB[a]), making the Mastercycler nexus X1 suitable for work within busy life science laboratories. A heating rate of 5°s means run times using the Mastercycler nexus X1 are very short, allowing several users to work on it during the course of a day. Up to three units can be combined for maximum throughput, and a booking schedule integrated into the software allows easy allocation of time to fit researchers' schedules. When in use, the Mastercycler may be connected to a computer network, supplying e-mail status updates on the progress of the PCR run.


The MethylEdge Bisulfite Conversion System offers an efficient method for rapidly performing bisulfite conversion and DNA clean-up within two hours, while maintaining DNA integrity to provide more intact, converted DNA for a variety of sensitive applications. MethylEdge requires only small amounts of input genomic DNA (100 pg to 2 μg). Using optimized conversion reagents, clean-up, and recovery methods, the system converts DNA at 90% efficiency with minimal fragmentation. The resulting DNA is suitable for use in downstream applications such as polymerase chain reaction, array, or sequencing assays. The kit includes all reagents necessary to perform 50 bisulfite conversion reactions. All MethylEdge reagents can be stored at room temperature and require minimal upfront preparation. The Promega MethylEdge Bisulfite Conversion System complements Promega nucleic acid purification kits for a wide variety of sample types and throughput levels, quantitation chemistries for both pre- and post-conversion, and Promega amplification technologies for detection.


The new ddPCR Library Quantification Kit for Illumina TruSeq sample preparation kits enables QX100 Droplet Digital PCR system users to precisely and directly measure amplifiable library concentrations for next generation sequencing. The TruSeq sample preparation method is the technology behind Illumina's MiSeq and HiSeq next generation sequencing platforms. Using the ddPCR Library Quantification Kit to quantify TruSeq DNA libraries maximizes the number of useable reads, enables consistent loading, and optimizes the utilization of every sequencing run. The resulting data provides additional measures of library quality not provided by other methods, including the percentage of nonamplifiable species such as adapter dimers as well as the size range of library inserts.


The FlexCycler2 is a modern thermal cycler which combines exceptional design with reliable technology in one system. Using the Quick-X-Change block exchange system, block modules can be exchanged within seconds, allowing the instrument to flexibly adapt to changing requirements. In total, six different mono-and twin-block modules are available, all of which can replace each other. The two independent blocks of the twin-block modules allow two different polymerase chain reaction (PCR) programs to be run simultaneously, thereby helping users avoid bottlenecks. The 96-well block module and the 48-well twin-block module, for optimization of new primer pairs, are also an available option with gradient function. The FlexCycler2 provides state-of-the-art heating and cooling rates, and excellent temperature uniformity enables reproducible conditions in all positions of the sample blocks. The user-friendly software, in combination with extensive additional software options, makes the FlexCycler2 the perfect system for challenging PCR applications.


The new Quantitative Multiplex DNA Reference Standard is the first of its kind and is intended for researchers assessing multiple biomarkers in a single assay using platforms such as next generation sequencing. As multiplexing assays and large tumor profiling projects become more common, standardization will be essential to enable confidence in experimental results. To date, a significant challenge has been access to reliable, renewable external reference standards. The novel Quantitative Multiplex DNA Reference Standard directly addresses this need by enabling researchers to quantify a range of detection thresholds for 11 cancer relevant mutations. This is accomplished across complex samples in a single assay in the form of renewable material originating from precisely engineered cell lines.

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