Technical Comments

Comment on “Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions”

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Science  10 May 2013:
Vol. 340, Issue 6133, pp. 682
DOI: 10.1126/science.1233195

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Ward and Kellis (Reports, 28 September 2012, p. 1675; published online 5 September 2012) found altered patterns of human polymorphism in biochemically active but non–mammalian-conserved genomic regions relative to control regions and interpreted this as due to lineage-specific purifying selection. We find on closer inspection of their data that the polymorphism trends are primarily attributable to mutational variation and technical artifacts rather than selection.

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