Technical Comments

Response to Comment on “Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions”

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Science  10 May 2013:
Vol. 340, Issue 6133, pp. 682
DOI: 10.1126/science.1233366

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Green and Ewing propose corrections to our methodology, which we incorporate and extend here. The improved methodology supports our initial conclusion of extensive lineage-specific constraint concentrated in ENCODE elements. We clarify that our estimate is dependent on the constrained and neutral references used, which can further increase the number of nucleotides involved, because a particularly stringent definition was initially used.

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