A Story of Swapped Ends

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Science  21 Jun 2013:
Vol. 340, Issue 6139, pp. 1412-1413
DOI: 10.1126/science.1241318

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It was dubbed the “Philadelphia chromosome,” named after the city where the abnormal chromosome was first described in 1960 (1). Peter Nowell, of the University of Pennsylvania, and David Hungerford, at the Fox Chase Cancer Center, had taken a close look at patients with chronic myeloid leukemia (CML) and found that regardless of sex, they had a very small chromosome. It was a turning point in cancer biology—the beginning of a story that would draw new attention to chromosome abnormalities as a cause of cancer, a phenomenon that still influences our understanding of the disease.