PerspectiveImmunology

Making Macrophages Eat Cancer

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Science  05 Jul 2013:
Vol. 341, Issue 6141, pp. 41-42
DOI: 10.1126/science.1241716

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Summary

A growing number of approaches to treating cancer, including antibodies, vaccines, and cell therapy, harness the immune system to seek and destroy cancer cells (1-3). Antibody-mediated immunotherapies have the potential to treat a large proportion of cancers. For decades, monoclonal antibodies have been used to directly target tumors (4, 5). However, cancer cells can develop resistance to antibodies and tumor regression may not persist in some patients. On page 88 of this issue, Weiskopf et al. (6) describe an antibody-mediated tumor immunotherapy in mice that overcomes the resistance of cancer cells to antibodies.