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Harnessing Stem Cells for Predictive Toxicology: Meeting the Challenges of Drug Discovery Today

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Science  12 Jul 2013:
Vol. 341, Issue 6142, pp. 199
DOI: 10.1126/science.341.6142.199-c


The core techniques used in toxicology studies have remained largely unchanged for over 40 years. It is acknowledged in the pharmaceutical industry that more predictive, earlier tests need to be established in order to prevent unsafe drugs progressing into the clinic and to stop potentially effective therapeutics being excluded from development. This recognition is driving the development of more relevant, specific, and reliable toxicology models and tests to improve drug safety and reduce the cost of development. In particular, the use of stem-cell–derived models can provide an opportunity to develop a transformative, integrated drug toxicity surveillance system.