PerspectiveGenetics

Genome Mosaicism—One Human, Multiple Genomes

Science  26 Jul 2013:
Vol. 341, Issue 6144, pp. 358-359
DOI: 10.1126/science.1239503

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Summary

With recent advances in genome-wide assays, it is becoming increasingly apparent that a human individual is made up of a population of cells, each with its own “personal” genome. Thus, mosaicism is perhaps much more common within multicellular organisms than our limited genomic assays have detected thus far, and may represent the rule rather than the exception. To what extent does it play a role in normal development and disease?