News & Analysis

Protein Designers Go Small

Science  06 Sep 2013:
Vol. 341, Issue 6150, pp. 1052
DOI: 10.1126/science.341.6150.1052-b

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Summary

Computer scientists would like to design proteins to bind to small druglike molecules in order to pave the way for new therapeutics and diagnostics. But such compounds have few chemical handles for parts of the protein to hold onto. Now, researchers led by David Baker at the University of Washington, Seattle, have developed a computer algorithm that cracked the code, at least for one drug, allowing them to design a protein that binds the molecule to the exclusion of its closest of kin.

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