PerspectiveRetrospective

Tony Pawson (1952–2013)

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Science  06 Sep 2013:
Vol. 341, Issue 6150, pp. 1078
DOI: 10.1126/science.1244986

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Summary

On 7 August 2013, the scientific community lost Tony Pawson, a pioneer in elucidating the mechanistic principles of intracellular signal transduction. His enduring legacy will be the discovery that the Src homology 2 (SH2) domain in one protein interacts with a phosphorylated tyrosine residue in another protein. This insight was the basis for his enormously influential idea that eukaryotic signaling systems comprise modular interaction domains that are used in combinations to propagate signals throughout the cell.