Translating Antibody Insights

See allHide authors and affiliations

Science  13 Sep 2013:
Vol. 341, Issue 6151, pp. 1151
DOI: 10.1126/science.1245018

You are currently viewing the summary.

View Full Text


Viruses that defy host immune responses and persist or recur take a huge toll on global human health. Many of these, including HIV-1, influenza viruses, and several flaviviruses (such as dengue, hepatitis C, and West Nile virus) rapidly proliferate, frequently mutate, and evolve highly variable surface structures. The effectiveness of such immune escape mechanisms has thwarted multiple attempts to create long-lasting and broadly protective vaccines.