Technical Comments

Comment on “Influence of HLA-C Expression Level on HIV Control”

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Science  13 Sep 2013:
Vol. 341, Issue 6151, pp. 1175
DOI: 10.1126/science.1241266

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Apps et al. (Reports, 5 April 2013, p. 87) found that high human leukocyte antigen C (HLA-C) expression favors HIV-1 control. However, as noted here, HLA-C was assessed with a monoclonal antibody (DT9) that cross-reacts with HLA-E. In the context of the available evidence, this is consistent with the idea that the two leukocyte antigens collaborate to keep the HIV-1 virus at bay.

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