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Response to Comment on “Influence of HLA-C Expression Level on HIV Control”

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Science  13 Sep 2013:
Vol. 341, Issue 6151, pp. 1175
DOI: 10.1126/science.1241854

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Lo Monaco et al. propose that human leukocyte antigen E (HLA-E) and HLA-C expression levels both contribute to HIV control. The minimal, flat level of cell surface HLA-E detectable by staining with available HLA-E–specific antibodies questions a role for differential HLA-E expression in determining HIV control. Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control.

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