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Science  13 Sep 2013:
Vol. 341, Issue 6151, pp. 1257
DOI: 10.1126/science.341.6151.1257-a

LIQUID CHROMATOGRAPHY-MASS SPECTROMETER

The Thermo Scientific Orbitrap Fusion Tribrid liquid chromatography-mass spectrometry (LC-MS) system, combines three mass analyzers—the quadrupole, Orbitrap, and linear ion trap—in a novel "Tribrid" architecture that offers unprecedented depth of analysis of complex biological samples. The Orbitrap Fusion combines and improves the quadrupole, linear ion trap, and Orbitrap technologies in an ultimately flexible research MS system—to arrive at an entirely new class of instrument. The Orbitrap Fusion instrument is revolutionary in achieving much greater proteome-wide coverage with much greater quantitative accuracy than ever before. One way the Orbitrap Fusion system can address throughput challenges is through tandem mass tags (TMT). This technique enables mass spectrometers to determine relative quantification of proteins in multiple samples simultaneously. The Orbitrap Fusion instrument dramatically increases depth and quality of data compared with previous tools to make TMT results far better.

ANTIBODY CAPTURE BEAD KIT

VersaComp Antibody Capture Bead kits are designed to set compensation for multicolor flow cytometry experiments by allowing researchers to utilize the same reagents used in their experiments. Two vials are provided. One contains positive beads, microspheres that capture conjugates in single-color stains, and the second contains negative beads, which provide particles with a measure of autofluorescence similar to unstained cells across the different excitation/emission wavelength combinations including those excited by violet lasers. Using positive and negative beads for each conjugate allows generation of a compensation matrix to correct for the spectral overlap of that conjugate into other channels. All mouse and rat isotypes, most hamster isotypes and rabbit polyclonal IgG are recognized by the positive beads. The fluorescence generated by the positive beads after capture is well separated from the fluorescence generated by the negative beads. The kits can be used with any cytometer including configurations with more than three lasers.

DRUG DISCOVERY SOFTWARE

Version 5.4 of the StarDrop software platform offers enhanced features to guide the design of novel, safe, and efficacious drugs by providing access to world-leading technologies for toxicity prediction and bioisosteric transformations. These new optional modules further extend StarDrop's capabilities to intuitively target high-quality compounds in drug discovery, reducing the time and cost to deliver drug candidates with an improved chance of success. The new Derek Nexus module for StarDrop provides knowledge-based predictions of the likelihood of a compound causing toxicity in over 40 endpoints, including mutagenicity, carcinogenicity, and hepatotoxicity. Seamlessly integrated with StarDrop's Glowing Molecule visualization, this new module guides the redesign of compounds to reduce the potential for toxicity. Stimulating the search for new optimization strategies, the BIOSTER module extends the existing Nova module that generates new compound ideas, prioritized against a project's required property profile.

'OMICS RESEARCH PLATFORM SOLUTIONS

The new TransOmics 2.0 informatics packages for proteomics and metabolomics/lipidomics are based on extended versions of the Nonlinear Dynamics Progenesis LC-MS and CoMet products. The TransOmics 2.0 informatics packages are specifically designed to process and visualize SYNAPT High Definition Mass Spectrometry (HDMS) 'omics data, denominated with Collision Cross Section (CCS), from the new Waters SYNAPT G2-Si HDMS mass spectrometer. Proteomics, metabolomics, and lipidomics researchers routinely acquire large, content-rich data sets that need to be efficiently reduced and intuitively visualized to facilitate the extraction of biologically significant results. TransOmics 2.0 has been developed specifically to address these issues and reveal the potential of CCS denominated 'omics data.

IMMUNOHISTOCHEMICAL ANALYSIS

A convenient set of tools are available for single-color and multicolor immunohistochemical (IHC) analysis, which feature MultiView multiplexing kits, PolyView reagents, and the market's broadest portfolio of HighDef Chromogens. MultiView detection kits offer a complete solution for multiplex IHC, providing increased efficiency, reduced reagent use, and preservation of precious tissue samples. Each kit includes biotin-free nanopolymer-based PolyView detection reagents to reduce endogenous biotin-associated background, HighDef chromogens for crisp two-color development, as well as buffers and blocking reagents. The flexibility of PolyView reagents and MultiView kits simplifies custom multiplex protocols to enable up to four-color staining within the same tissue sample. The palette of HighDef chromogens provides the most choice in color options, featuring HighDef Yellow horseradish peroxidase (HRP), and including multiple HRP and alkaline phosphatase options. The portfolio also includes streptavidin-based SAView detection kits for improved sensitivity and background compared to ABC detection protocols, also compatible with HighDef chromogens.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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