Policy ForumMedicine

Mitochondrial Replacement, Evolution, and the Clinic

Science  20 Sep 2013:
Vol. 341, Issue 6152, pp. 1345-1346
DOI: 10.1126/science.1237146

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  1. Health outcomes of intraspecies experimental MR in animals.

    Studies either invasively removed the nucleus by placing it into the enucleated donor oocyte (blue shading) or replaced mitochondria by repeatedly crossing foreign mitochondrial genotypes into nuclear backgrounds (green shading) (see table S1 for details). All species share the same 37 mitochondrial encoded genes. Studies of health effects of MR on vertebrates that have reached reproductive ages are lacking.