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Science  20 Sep 2013:
Vol. 341, Issue 6152, pp. 1409
DOI: 10.1126/science.341.6152.1409-a


The Vibralevel DSM Dual Stiffness Isolation Mount is a new concept in vibration isolation for moving load applications. Providing the optimal combination of damping and vibration isolation, the Vibralevel DSM is a cost-effective alternative to active vibration isolation systems. Designed primarily for applications where a moving load is supported on vibration isolation mounts, the Vibralevel DSM virtually eliminates platform tilt by activating the "stiff" mode when a load undergoes an aggressive move. On a signal from the machine controller, it transitions from a softer vibration isolation system to a stiffer support platform within 500 ms. Upon receipt of a signal such as "servo-in-position" when the move is complete, the system reverts to "soft" mode, providing the vibration isolation required for accurate placement or inspection. The Vibralevel DSM is ideal for applications involving both shifting loads and the need for pinpoint positioning applications and is well suited to die bonders, systems with robotic arms, and pick-and-place machines.


The Aqualog, the only simultaneous absorbance and fluorescence system that measures CDOM (colored dissolved organic matter) in water, is 100 times faster than previous fluorescence methods, and now offers both lower absorbance and fluorescence excitation wavelengths down to 200 nm, and extended emission coverage up to 800 nm. To support the new ozone-producing lamp, a deozonating scrubbing filter has been included. Sample Queue software has also been added for automatic, continuous data collection of excitation emission matrices for up to 1,000 samples without interruption. The software is compatible with multi-position sample changers and flow-through cells. An enhanced Solo software package from Eigenvector Inc. enables rapid import to multivariate modeling and provides rapid, automated generation of component identification and quantification tables. The Solo Parallel Factor Analysis has been upgraded with split-half validation analysis and an improved Rayleigh and Raman scattering masking toolkit.


The Dionex Corona Veo is an advanced charged aerosol detector (CAD) for liquid chromatography (LC) engineered to increase the effectiveness of CAD technology with expanded low-flow capability and additional sensitivity compared to its previous detectors. A new FocusJet concentric nebulization system was developed specifically for the Corona Veo detector to enhance performance, especially for the detection of semi-volatile compounds. Compared with its past systems, the new aerosol flow path is improved for a wider range of usable LC mobile phase compositions and can accommodate a broader range of separation chemistries and column technologies. The Corona Veo detector is designed to make the universal detection benefits of CAD accessible with the speed and resolution of UHPLC at sub-nanogram sensitivity levels. The detector works with non-volatile and many semi-volatile compounds, from large to small molecules. The Corona Veo detector can be used to evaluate relative analyte concentrations, even when standards are not available.


The new samX platform is designed for real-time, label-free biomolecular interaction assays, and includes advanced acoustic wave biosensor technology. Based on SAW's Surface Acoustic Wave technology, the biosensors measure changes in mass and viscoelasticity at the chip surface based on changes in the high-frequency acoustic oscillations running across the chip surface. This innovative approach is complementary to other biophysical techniques, such as surface plasmon resonance and quartz crystal microbalance for measuring protein interactions, and can also be used for samples and applications that are difficult to analyze by these other methods, thus providing additional information and insights. The samX platform is ideally suited to the study of native membrane proteins and protein complexes such as the 7TM G-protein coupled receptors, either as membrane fragments or within liposome or vesicle particles. Such complexes can be very challenging to analyze by traditional biosensor platforms.


A new range of 96-well format 3D Spheroid Cell Proliferation/Viability Assays provide a new tool to allow cell-based assays to be carried out in 3-D. The new assay provides a useful tool for modeling tumor response in vitro. The kit utilizes a 3D Culture Qualified 96 Well Spheroid Formation Plate alongside a specialized Spheroid Formation Extracellular Matrix to drive aggregation and/or spheroid formation of cells. Upon completion of spheroid formation, the spheroid may be treated with pharmacological agents to evaluate tumor viability after drug treatment. Tumor spheroid expansion is visualized microscopically and can be quantitated through image analysis software for real-time and label-free evaluation. At the conclusion of the assay, cell viability may be assessed by fluorescence using Resazurin. The assay offers an in vitro, standardized, three-dimensional, high-content format for inducing multicellular tumor spheroid formation and quantitating cell viability within the spheroids in response to pharmacological treatment.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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