PerspectiveCell Biology

Stalemate in the Golgi Battle

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Science  27 Sep 2013:
Vol. 341, Issue 6153, pp. 1465-1466
DOI: 10.1126/science.1245656

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The Golgi—a series of flattened membrane sacs (cisternae)—lies at the hub of a eukaryotic cell's endomembrane system. The routes taken by transiting cargo and the Golgi's resident enzymes have been a matter of long-standing controversy. The two most popular models—stable cisternae versus cisternal maturation—have attracted support and criticism in almost equal measure (1). Two recent papers, aimed at providing a decisive answer for one of the models, instead offer conflicting interpretations of similar data.