Expanding the Scope of Fluorine Tags for PET Imaging

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Science  25 Oct 2013:
Vol. 342, Issue 6157, pp. 429-430
DOI: 10.1126/science.1245011

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Millions of patients undergo PET (positron emission tomography) imaging every year, but there is a critical unmet need for new PET imaging probes capable of diagnosing and monitoring a multitude of diseases. One of the most versatile radionuclides for PET imaging is 18F, but rapid chemical synthesis of any probe based on 18F is essential because its physical half-life is only 110 min. Huiban et al. (1) recently reported an improved method for labeling trifluoromethylarenes (Ar-CF3) with 18F that could greatly facilitate the development and adoption of new PET probes and allow the site of action of existing drugs to be identified.