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Science  25 Oct 2013:
Vol. 342, Issue 6157, pp. 485
DOI: 10.1126/science.342.6157.485-a

WATER SORPTION ANALYZER

The Aquadyne DVS-2HT is the latest in the family of precision water sorption analyzers, joining the Aquadyne DVS-1, single-balance unit, and the Aquadyne DVS-2 dual-balance unit. The Aquadyne DVS water sorption analyzer is capable of analysis temperatures from 10°up to 85° The Aquadyne DVS instruments are used to accurately measure the amount of water vapor a sample can adsorb, and the rate at which it is adsorbed and desorbed. This is accomplished by gravimetrically monitoring the process while precisely controlling the amount of water in a flowing stream of nonreactive gas; a technique referred to as dynamic vapor sorption (DVS). The instruments use precision microbalances housed in a temperature-controlled housing, which enables the measurement of miniscule changes in weight in the microgram range. This high sensitivity along with precise temperature and humidity control ensures accurate, reproducible results every time.

BASEMENT MEMBRANE EXTRACTS

Two new formulations of Basement Membrane Extract (BME) are now available: Cultrex BME 2 (organoid growth matrix) and Cultrex BME 3 (xenograft/tumor graft matrix). The new products have been developed to address the heterogeneous nature of tissue and organ microenvironments that not only arise from organ specific stromal cells, growth factors, proteoglycans, and protein composition but also from the stiffness or tensile strength of the BME. BME 2 is based upon a proprietary formulation that is higher in tensile strength than original Matrigel or Cultrex BME. This growth factor reduced product is recommended for organoid growth applications including 3-D cell culture from stem cells. By comparison, BME 3 has been developed to be physiologically aligned with the in vivo tumor environment and is recommended for xenografts, tumor grafts, and other in vivo applications. Cultrex BME is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm tumors.

METABOLITE-TESTING REAGENT

New metabolite-testing reagent sets have been designed to determine the concentration of iron and phosphate, which are two parameters relevant for cell growth and productivity during fermentation processes. The tests are designed for applications in research and bio-manufacturing process development and will allow the measurement of iron (complexed iron/Fe3+ ions) and phosphate on Cedex Bio instruments. The new tests can be easily installed by barcode reading through the customer supporting the flexible testing concept. Offered as liquid-stable formulation, they are ready for use and do not require manual dilution or pipetting steps. With their increased precision, accuracy, and long calibration intervals, the new iron and phosphate tests offer cost-effective and convenient testing with less hands-on time for users.

MOLECULAR ACTIVITY ANALYSIS

The ground breaking new science in Activity Miner helps researchers optimize their leads by identifying the key 3-D structural and electrostatic changes that impact molecular activity. Activity Miner explores the structure activity landscape of a set of molecules. For each pair of molecules, the difference between them in electrostatics, shape, and structure is compared to the difference in activity. A small change in structure or electrostatics that results in a large change in activity is known as an activity cliff. Conversely, large structural changes resulting in little or no change in activity indicate bioisosteres. Activity Miner uses Cresset's molecular fields so that 3-D electrostatic and shape similarities can be analyzed as well as 2-D structural activity. This makes it meaningful to compare pairs of structurally diverse compounds and gives a more realistic insight into activity relationships. Activity Miner is available for beta testing over the summer. The full version will be available in the next release of Cresset's Forge and Torch.

AUTOMATED TISSUE PROCESSOR

The unique state-of-the-art tissue processor, LYNX II, is not only compatible with all plastic resins but with paraffin waxes as well. LYNX II is the successor of Lynx Tissue Processor with several enhancements, including capabilities to perform optional processing of larger size samples for histology. The LYNX II holds 24 reagent vials for electron microscopy (EM) processing and provides an option for histology processing (HP) using 12 larger size reagent vials. In both EM and HP modes, LYNX II has two independently controlled heating/cooling stations. The tissue processor features 10 programs for EM and 10 programs for HP; two independently controlled heating/cooling stations; easy replacement of reagent carousel; paraffin processing; sample agitation; vacuum infiltration during processing; and a choice of plastic and metal containers for improved chemical compatibility and heat transfer. An optional external media-based interface to a PC is offered for ease of programming.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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