Science Webinar Series

Culturing Patient Cells for Cancer Immunotherapy: Challenges and Opportunities

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Science  15 Nov 2013:
Vol. 342, Issue 6160, pp. 875
DOI: 10.1126/science.342.6160.875-c

Summary

Immunotherapy that uses autologous cells has recently shown increasing success. This procedure, however, requires the generation of sufficient, high-quality cells for infusion into patients. Functionally closed, automated, single use cell culture systems have significant advantages over the open, static systems that are commonly used. Keeping these systems small and efficient, while at the same time producing a sufficient number of cells is a challenge. Enabling high cell density culture is very important in order to minimize the total space required in a manufacturing or clinical development laboratory setting. However, achieving these high cell densities without compromising the quality of cells can be a challenge. This webinar will examine the conditions contributing to a healthy cell culture environment and explore ways to optimize high cell density culture.