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Science  22 Nov 2013:
Vol. 342, Issue 6161, pp. 999
DOI: 10.1126/science.342.6161.999-a

CNV AND LOH ARRAY

The new CytoSure Consortium Cancer +SNP array (4x180k) allows the simultaneous detection of copy number variation (CNV) and loss of heterozygosity (LOH), with a SNP resolution that enables reporting of LOH at 10Mb. Focusing on content recommended by the CCMC, an international organization of clinical cytogeneticists, molecular cytogeneticists, and molecular pathologists, this targeted array covers over 500 cancer genes and 130 cancer-associated genomic regions for haematological malignancies and solid tumours. The CCMC-approved standardized array design is intended to improve clinical research quality and promotes collaboration and communication between cancer cytogenomics laboratories. The new array will be the latest addition to a range of OGT microarrays specifically designed for detecting CNV and LOH on a single array for cancer research. Due to the unique design of OGT's SNP probes, there are no changes to the standard aCGH protocol, no restriction digest is required, and any reference sample can be used.

  • Oxford Gene Technology

  • For info: +44-(0)-1865-856826

  • www.ogt.com

LAB SAFETY SHIELD

The Lab Safety Shield has been designed to neatly fit around popular brands of stirrer hotplate to provide protection for chemists from draughts, splashes, aerosols, and spills. Ideal for use where fumehood space is at a premium, the compact and highly affordable Lab Safety Shield provides additional protection to chemists undertaking applications such as heated parallel reactions in tubes. The device also beneficially shields reactions from the cooling effect of fumehood ventilation, particularly important when consistent and reproducible heating to parallel experiments is required. Manufactured from robust 5 mm polycarbonate, the Lab Safety Shield is resistant to a wide range of laboratory solvents and is temperature-resistant to 170° Designed with a small footprint (29.5 x 16 x 17 cm) to minimize use of valuable fumehood space, the shield maintains access to hotplate controls and gives good all-round visibility of the reaction or process.

SEMICONDUCTOR CHIPS

The Ion PGM solution now significantly exceeds its competitor on the major performance metrics for benchtop sequencing. The performance gains are the result of upfront sample prep automation, new Ion PGM semiconductor chips that deliver up to 10-fold greater throughput, and improved variant calling with Torrent Suite Software v3.6. Combined with Ion AmpliSeq technology, targeted DNA and RNA sequencing using the Ion PGM solution is superior. The Ion PGM solution offers the fastest and simplest workflow—single-day assay, from sample to annotated variants; highest sensitivity for basic and clinical research applications; and lowest cost per sample. Ion Torrent semiconductor sequencing makes high-quality, next generation sequencing affordable with the Ion PGM System at a fraction of the cost of the alternative.

DIGITAL PCR SYSTEM

The QX200 Droplet Digital PCR (ddPCR) system is the only digital polymerase chain reaction (PCR) system that works with EvaGreen and TaqMan hydrolysis probes (reagents that are used with the instrument) to provide users more flexibility in the design of their digital PCR experiments. The new system can be used with the company's recently launched 75 Droplet Digital PCR-validated assays (tests) for cancer mutation detection and genomic variations (gene copy number) to make running an experiment easier. Digital PCR provides researchers a tool for the detection of rare mutations (including distinguishing rare sequences in tumors), precise measurement of copy number variation, and absolute quantification of gene expression. ddPCR has been widely embraced, demonstrating a level of sensitivity and simplicity not available by any other means.

LIQUID DISTRIBUTION

The Calibrex organo 525 and the Calibrex solutae 530 smoothly dispense exact volumes of liquid reagents directly from bottle or flask. With its ground glass plunger, the organo 525 is ideal for dispensing organic liquids and noncrystallizing solutions. The solutae 530 has a PFA-coated plunger that is resistant to salt solutions, weak and strong acids, and bases, which prevents the plunger and barrel from seizing together. Scientists can check continuously updated chemical compatibility data by scanning the QR code imprinted on each unit. Precise dispensing volumes up to 25 mL, 50 mL, and 100 mL are easily set with one hand using the spring loaded sliding cursor, or by using a classic screw button supplied with each dispenser. No tools are required for cleaning and maintenance—users can calibrate the dispensers using the integrated key located under the plunger cap. Calibrex dispensers can be autoclaved fully assembled at 121°250°

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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