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Science  29 Nov 2013:
Vol. 342, Issue 6162, pp. 1121
DOI: 10.1126/science.342.6162.1121-a


PerFix-Expose and PerFix-nc are innovative new reagent kits for intracellular staining, which minimize sample manipulation for a streamlined workflow that delivers high-quality results. Developed for use on Beckman Coulter's Gallios and Navios series flow cytometers and compatible with all Beckman Coulter Life Sciences' fluorochromes, the kits enable a clear focus on the cytoplasmic and nuclear compartments of the cell. PerFix-Expose (phospho-epitope exposure kit), which helps scientists identify and explore complex intracellular signaling pathways disrupted by cancer and other diseases, allows fluorochrome-coupled antibodies and other probes to enter into cells, their nuclei, and other cell compartments, where they bind to proteins relevant to signaling pathways that have been disrupted by disease. Cell fixation is accomplished using a cross-linking agent, while permeabilization of white blood cells and lysis of red blood cells is achieved using a detergent. A denaturing agent "unmasks" proteins bound to other proteins or DNA.


Oncomine Next Gen Sequencing Power Tools are an analytics offering that will allow cancer researchers to explore results from in-depth analysis of next generation sequencing (NGS) data, including data from The Cancer Genome Atlas. In total, more than 4,500 paired tumor and normal samples have been analyzed to date. Oncomine NGS Power Tools constitutes a suite of software tools that enable cancer researchers to easily survey novel predicted driver mutations and gene fusions across all cancers and within two-dozen specific cancers types as well as explore simple summary analyses that integrate multiple types of gene and pathway aberrations with clinical data. In addition to basic research applications, the NGS tools also provide a foundation for specialized biomarker services to pharma and biotech customers in their efforts to evaluate NGS data for biomarker and companion diagnostic development.


The TransIT-X2 Dynamic Delivery System is an innovative polymeric system for high-efficiency nucleic acid delivery. TransIT-X2 can be used for independent or simultaneous delivery of DNA and siRNA. The TransIT-X2 Dynamic Delivery System offers researchers: efficiency with an exceptional broad spectrum transfection; versatility with cutting-edge delivery of plasmid DNA and/or siRNA; and technology with novel nonliposomal polymeric delivery. This system provides superior delivery of plasmid DNA and siRNA into a vast array of cell types.


Ease of use and unmatched accuracy make the XL-1000 UV crosslinker ideal for many applications including: elimination of polymerase chain reaction contamination, crosslinking of DNA and RNA, nicking ethidium-bromide-stained DNA, gene mapping, RecA mutation screening and testing, ultraviolet (UV) sterilization, UV-induced polymerization, UV intensity monitoring, and many other UV-dosage applications. Researchers appreciate the XL-1000's "smart" microprocessor controller and unique, true UV-monitoring circuitry, which allows users to obtain error-free results faster, safer, and more accurately than previously possible. The Spectrolinker ensures reliable crosslinking in record time by covalently binding nucleic acids to membranes in less than 30 seconds. The UV-monitoring circuitry guarantees that the set dosage is always delivered, protecting important test results from washout damage. The Spectrolinker greatly increases the visibility of samples on autoradiograms, which results in superior analysis and extra-sharp, extremely clear, publication-quality photodocumentation. The XL-1000 has four operation modes, built-in "help" messages, and an auto-repeat function.


The next generation of the EVO series scanning electron microscope (SEM) is designed for material and life science applications. Customer productivity and imaging performance are dramatically increased by the SEM's workflow automation, beam deceleration technology, and class leading HD BSE detector. EVO reduces a typical workflow from over 400 steps to just 15. Workflow productivity is improved by automated image settings such as the beam alignment, magnification and focus, allowing the imaging of areas of interest in the shortest possible time. A user-friendly mid-column click-stop aperture changer is introduced for reliable and reproducible results. EVO allows imaging of exceptionally fine surface details with crisp contrast. Beam deceleration technology and a high definition BSE detector provide images rich in topographical information. The EVO series continues to offer full environmental capabilities, three chamber sizes, and class-leading X-ray geometry.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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