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Evolution of Vertebrate Transcriptional Regulator Binding

Science  06 Dec 2013:
Vol. 342, Issue 6163, pp. 1186
DOI: 10.1126/science.1247569

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Vertebrates contain hundreds of different cell types that develop and maintain their phenotypic identity by a combination of genomic and epigenomic regulation. What are the regulatory mechanisms that enable one vertebrate genome to give rise to this magnificent diversity? And how are these mechanisms exploited over evolutionary time to allow for divergence and to give rise to new functions and ultimately species?