PerspectiveMolecular Biology

Finding the Right Partner in a 3D Genome

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Science  13 Dec 2013:
Vol. 342, Issue 6164, pp. 1333-1334
DOI: 10.1126/science.1246106

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DNA integrity is frequently compromised as a result of exposure to cytotoxic agents, as well as the normal wear and tear of cellular processes like transcription and replication. DNA double-strand breaks (DSBs) are arguably the most dangerous type of DNA damage as they can lead to chromosomal translocations when their repair joins noncontiguous genomic regions together. Indeed, numerous malignancies have been associated with signature translocations in which an oncogene becomes deregulated through joining with another gene that exerts control over its expression.