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Science  13 Dec 2013:
Vol. 342, Issue 6164, pp. 1393
DOI: 10.1126/science.342.6164.1393-a


The ScanLater Western Blot Detection System combines Western blot membrane detection with a multimode microplate reader platform, eliminating the need to acquire a separate dedicated Western blot system, saving both lab space and budget. The system is compatible with Molecular Devices' SpectraMax i3 and SpectraMax Paradigm Platforms. ScanLater System uses time-resolved fluorescence (TRF)-based Western blot detection, an optimal detection method that reduces stray excitation light, resulting in lower background noise and higher sensitivity. The system comprises the ScanLater Western Blot Detection Cartridge, ScanLater Western Blot Kit, and image acquisition software powered by SoftMax Pro Software. ScanLater Western Blot Kits contain europium-labeled secondary antibodies designed to work with existing primary antibodies without further optimization. This substrate-free method of Western blot detection not only outperforms traditional chemiluminescence and fluorescence-based Western blot detection, but also allows membrane detection at any time.


The new range of SimpleStep ELISA kits have a greatly simplified protocol when compared with standard multistep enzyme-linked immunosorbent assays (ELISAs), providing significant time-savings and ease of use. Offering enhanced performance, SimpleStep ELISA kits are single wash, colorimetric sandwich ELISAs which retain the familiar process and data outputs of a traditional ELISA kit. The kits require no specialized training or instrumentation and, in contrast to standard ELISA, achieve increased accuracy due to reduced sample handling steps. Additionally, a more efficient in-solution binding process provides superior sensitivity and specificity. The SimpleStep kits are ideal for studying intra- or extracellular signaling pathways or for cancer biomarker research. Numerous new kits are being added to the already extensive range each month. The kits are available in convenient off-the-shelf one-, two-, or four-target conformations. Custom multitarget kits are also available, allowing customers to select analyte combinations specific to their research.


The ACQUITY QDa Detector is the first mass detector to bring high-quality, mass spectral data to chromatographic separations. Designed as a synergistic component of a chromatographic system, the ACQUITY QDa Detector is compatible with ACQUITY UltraPerformance LC (UPLC), ACQUITY UltraPerformance Convergence Chromatography (UPC2), Alliance high-performance liquid chromatography (HPLC), and supercritical fluid chromatography (SFC) and LC-based purification systems. The ACQUITY QDa Detector addresses the barriers of complexity, size, and cost that have hindered the adoption of mass spectrometry for everyday use. It is purposefully designed for analytical scientists who need mass spectral data without the complexity of a mass spectrometer. With the on/off simplicity that analytical scientists have long wanted from mass spectrometry, the ACQUITY QDa Detector fully automates sample analysis and eliminates sample-specific adjustments for certainty in sample results, from user to user and system to system.


The new Model 2304 Automated Protein Denaturation System completely automates protein stability determinations using chemical denaturation. Developed to facilitate the formulation of biologics in a safe and stable form, the system uses intrinsic or extrinsic fluorescence to monitor the conformational changes associated with protein unfolding (denaturation) and automatically generates complete protein stability curves. Up to 96 different formulations, process conditions, or individual protein constructs can be evaluated for relative stability, and an individual stability curve generated for each. Sample preparation, data collection, data analysis, and stability report generation are all automated. The free energy (∆G) of protein unfolding is automatically calculated for each formulation condition or each individual protein construct. Chemical denaturation, a well-established technique, provides reliable thermodynamic values for protein stability and allows solution conditions such as buffer composition, buffer strength, pH, ionic strength, excipient composition, excipient concentration, and protein concentration to be effectively assessed and optimized.


The VisiGlo HRP Chemiluminescent Substrate Kit with picogram sensitivity is now one of three VisiGlo options available after the addition of VisiGlo Prime and VisiGlo Select HRP Chemiluminescent Substrate Kits to their repertoire. The different formulations, from low to high sensitivity, allow HRP detection across a broad range of Western blotting conditions. The new VisiGlo Prime HRP Chemiluminescent Substrate Kit is ideal for accurate protein quantitation, with a linear dynamic range of signal versus protein concentration encompassing over three orders of magnitude. VisiGlo is best suited for moderate- to high-abundance protein detection, while VisiGlo Select offers the most intense signal for use in blotting with low-abundance targets. For sensitivity and accurate quantitation, VisiGlo Prime's wide dynamic linear range is an ideal choice. The chemiluminescent signals of the three VisiGlo options are all compatible with CCD and film imaging. VisiGlo Select also works with fluorescent imaging systems.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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