PerspectiveMolecular Biology

Ribose—An Internal Threat to DNA

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Science  17 Jan 2014:
Vol. 343, Issue 6168, pp. 260-261
DOI: 10.1126/science.1248234

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Our genomes possess an intrinsic level of instability, resulting both from an inherent lability of the chemical bonds of the deoxyribonucleotides that make up DNA and from their vulnerability to endogenous reactive molecules within the cell. Yet, there is an additional, more insidious, source of attack on our genetic material: the misincorporation of RNA, the chemical sister of DNA.