PerspectiveBiochemistry

Protein Folding, Interrupted

+ See all authors and affiliations

Science  14 Feb 2014:
Vol. 343, Issue 6172, pp. 743-744
DOI: 10.1126/science.1249405

You are currently viewing the summary.

View Full Text

Summary

Globular proteins start their lives as linear chains of amino acids coming off the ribosome. Proteins must then fold into specific three-dimensional structures to be functional. In 1957, the first such structure, of myoglobin, was determined at atomic resolution (1). Fifty-six years and 90,000-plus protein structures later (2), we have a very good idea of the necessary requirements for a stable, specific structure. Key to these requirements is the formation of a well-packed, largely anhydrous core (3). Yet, on page 795 of this issue, Sun et al. (4) report an antifreeze protein with a core mostly consisting of water.