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Science  14 Feb 2014:
Vol. 343, Issue 6172, pp. 799
DOI: 10.1126/science.343.6172.799-a

DEEP-IMAGING MULTIPHOTON SYSTEM

The new FluoView FVMPE-RS is a dedicated multiphoton microscope system, which enables high-precision, ultrafast scanning and stimulation. This system allows researchers to see deep within specimens, take measurements at the highest speeds, and capture images, even when working under the most demanding conditions. With its high-speed and high-precision performance, the FVMPE-RS is designed for electrophysiology and optogenetics studies. It is also a good match for applications such as high-speed calcium and in vivo imaging, peristalsis and blood flow studies, mosaic imaging, connectomics and functional brain imaging, stem cell research, and any field that requires precise co-localization, uncaging, simultaneous imaging/stimulation, extensive real-time signal processing, or multipoint mapping. Its design offers ready adaptability for researchers who design their own custom-built systems as well. The precision timing on the system allows for microsecond repeatability and control of multiple imaging and stimulation protocols as well as millisecond repeatability over days of time-lapse imaging.

SEQUENCING PANEL

The TruSight One Sequencing Panel is the industry's broadest sequencing panel, targeting 4,813 genes with known associated clinical phenotypes. Clinical research laboratories can use this panel to expand existing menus, streamline workflows, or create an entire portfolio of sequencing options, with benefits including increased productivity, reduced handling errors, and decreased costs. The power of the TruSight One Sequencing Panel is enhanced by Illumina's user-friendly VariantStudio analysis and reporting software. To coincide with the introduction of the TruSight One Sequencing Panel, VariantStudio will offer new features that expand annotation and filtering capabilities. These features include support for enabling family-based filtering (mother, father, child, and siblings), providing variant classifications, and generating ready-to-use reports. In addition, the TruSight One Sequencing Panel can be used to create dozens of "virtual subpanels" to fit the needs of any clinical researcher seeking to understand the genetic basis of disease.

DNA METHYLATION ANALYSIS KITS

New, high-efficiency BioArray conversion kits for detection of 5 mC and 5 hmC modifications (Express DNA Methylation Kit,Blood & Tissue DNA Methylation Kit, andBioArray 5-hmC Methylation Kit) allow for resolution of single-nucleotide changes without the introduction of DNA damage. Unique features such as capacity for multiple sample inputs, rapid processing time, and high conversion efficiency rate, provide enhanced flexibility without sacrificing performance.For researchers requiring downstream analysis products, new enzyme-linked immunosorbent assay (ELISA)-based detection kits for 5 mC and 5 hmC exhibit high specificity comparable to mass spectrometry analysis and are amenable to high throughput processing. Complementing the ELISA kits is a new real-time polymerase chain reaction-based detection platform, theBioPanel DNA Methylation Detection Kit for Human Pluripotent Stem Cells. This product is designed to quantify the percentage of DNA methylation in six gene promoters, RAB25, NANOG, PTPN6, MGMT, GBP3, and LYST.

ION CHANNEL DRUG SCREENING

The new SyncroPatch 384 Patch Engine (PE) propels ion channel drug discovery to a new level. Designed for seamless integration into process-automated drug screening environments, the Patch Engine is equipped with 384 patch clamp amplifiers and an advanced 384 channel liquid handling robot. The SyncroPatch 384 PE is the high-quality, automated patch clamp system able to finally thrust gold standard electrophysiology from secondary to primary ion channel drug screening. Allowing for up to 20,000 data points per day, it is the most efficient platform on the market for high quality, ion channel recordings. This efficiency is primarily due to fully parallel measurements from 384 cells, the 384-channel pipettor, and exceptionally efficient control and analysis software. Both hardware and software have been fully tested and validated with leading players in industrial ion channel drug development to provide optimum performance in true high throughput ion channel screening.

ddPCR LIBRARY QUANTIFICATION KIT

The newdroplet digital polymerase chain reaction (ddPCR) library quantification kitis designed for Ion Torrent library preparation. Used withBio-Rad's QX200 Droplet Digital PCR system, the new kit provides researchers with the ability to precisely and directly measure amplifiable library concentrations. The Ion AmpliSeq library kit is used to prepare libraries for Ion Torrent next generation sequencing systems. Using the ddPCR library quantification kit to quantify Ion AmpliSeq gDNA and RNA libraries maximizes the number of useable reads, enables consistent loading, and optimizes the utilization of every sequencing run. The resulting data provide additional measures of library quality not provided by other methods, including the percentage of nonamplifiable species such as adapter dimers and the size range of library inserts. Additional key benefits of the ddPCR library quantification kit for Ion Torrent systems include superior performance, visualization of library quality, and efficient utilization of sequencing runs.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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