News & AnalysisVirology

A Bid to Thwart HIV With Shot of Long-Lasting Drug

Science  07 Mar 2014:
Vol. 343, Issue 6175, pp. 1067
DOI: 10.1126/science.343.6175.1067

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Antiretroviral drugs can protect people from becoming infected by HIV. But so-called pre-exposure prophylaxis, or PrEP, only works if people take pills daily—which studies show they have trouble doing. Now, monkey experiments with an integrase inhibitor that's injected show how a single shot protects them from the AIDS virus for 11 weeks on average. The drug lasts even longer in humans, which may provide a promising new approach to PrEP.