A Genomic Road Map for Complex Human Disease

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Science  07 Mar 2014:
Vol. 343, Issue 6175, pp. 1087-1088
DOI: 10.1126/science.1251426

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Despite the successes of genome-wide association studies (GWAS) in identifying genetic connections with human disease, it has become clear that interpreting these data requires a clear understanding of how these new risk genes are regulated. On pages 1118 and 1119 of this issue, Fairfax et al. (1) and Lee et al. (2), respectively, elucidate networks of genetic regulation in the context of the human innate immune system and show how this information can be directly applied to understanding the genetics of autoimmune disorders.