Interneurons from Embryonic Development to Cell-Based Therapy

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Science  11 Apr 2014:
Vol. 344, Issue 6180, 1240622
DOI: 10.1126/science.1240622

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Interneurons Reach Far and Wide

Interneurons in the brain have been garnering increasing attention. Southwell et al. (10.1126/science.1240622) review the development of this unique class of neurons. The cells migrate long distances during brain development. Transplantation of interneurons derived from embryonic stem cells is yielding insight into disease processes and may have therapeutic potential. For example, Parkinson's disease, epilepsy, certain psychiatric disorders, and even some sorts of chronic pain either involve interneurons or may respond to transplanted interneurons.