News & AnalysisToxicology

'Humanized' Mouse Detects Deadly Drug Side Effects

Science  18 Apr 2014:
Vol. 344, Issue 6181, pp. 244-245
DOI: 10.1126/science.344.6181.244

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An experimental hepatitis B drug that looked safe in animal trials tragically killed five of 15 patients in 1993. Now, researchers have engineered a mouse with a humanized liver that readily detects the drug's toxicity and may serve as a novel toxicity screen for other drugs that have yet to enter human trials.