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Science  18 Apr 2014:
Vol. 344, Issue 6181, pp. 325
DOI: 10.1126/science.344.6181.325-a

SORPTION MICROBALANCE

XEMIS is a new high-accuracy sorption microbalance for precision weighing in extreme environments. The XEMIS allows the analysis of gas and vapor sorption by materials at pressures as high as 200 bar and at temperatures between 77 K and 500°C. It can also handle aggressive species. This combination of conditions was not previously achievable with commercial gravimetric sorption analyzers. Featuring new exosensing technology, the unique design of the XEMIS removes the sensing and control mechanisms from the microbalance chamber and out of the wetted zone. This allows sorption analysis with hazardous and aggressive species without compromising measurement accuracy or resolution. Furthermore, unparalleled weight measurement stability is provided by the symmetric geometry beam balance design. The intrinsic long-term stability of the XEMIS, with no need to rezero or recalibrate the balance, ensures the capture of true sorption behavior and provides the ability to record full kinetic data over extended timescales.

NEURAL PROGENITORS CELLS

A new range of neural progenitor cells and cerebral cortical neurons derived from human induced pluripotent stem (iPS) cells is now available. Using cutting-edge stem cell technologies to generate high-purity human neural cells and neurons, AMSBIO is able to provide healthy and Alzheimer's disease patient-derived cerebral cortical neurons and neural progenitor cells. This accessible, in vitro human-based system offers a platform to build human cellular models to study conditions including Alzheimer's, autism, epilepsy, traumatic brain injury, and stroke. Derived using integration-free fully defined neural induction conditions, these cells are electrically active, form functional synapses in vitro and can be transplanted into animal models. Available in industrial quantities, these cerebral cortical neurons and neural progenitor cells are supplied with extensive functional and molecular characterization data. All products are supplied ready-made and remain viable in culture for months to facilitate reproducible and long-term studies.

BIOREACTOR SYSTEM

The new CellMaker PLUS is a highly flexible, robust, and easy-to-use single-use bioreactor system. The system includes improved control software and comes complete with full pH and dissolved oxygen (DO) control. The system is designed for microbial applications, especially bacterial and yeast cell culture, providing the highest DOs and improved yields of soluble protein in oxygen-hungry cell types such as E. coli. Production, quality control, and service of the fully CE marked system is conducted from the new Cellexus facilities in Cambridgeshire (UK) which is ISO9001 certified. The new CellMaker PLUS has been proven to provide highly efficient oxygen transfer, allowing high rates of cell growth outperforming bacterial and yeast cell culture in other systems. It uses CellMaker PLUS Bags which are unique, next generation single-use, disposable cell culture bags in which the cells are grown with fast setup times, no cleaning requirements and no cross-contamination.

Grp78/BiP ELISA KIT

Unique enzyme-linked immunosorbent assays (ELISAs) for protein homeostasis (proteostasis), neurodegenerative disorders, and cancer research are now available with the high-sensitivity Grp78/BiP ELISA Kit. Grp78/BiP is an endoplasmic reticulum (ER)-specific homologue of Hsp70, serving as a critical stress-sensing chaperone and regulator of the unfolded protein response. This quantitative ELISA kit offers sensitivity to enable quantification of both normal and upregulated levels of Grp78/BiP, detecting as little as 8.4 ng/mL of Grp78/BiP in human, mouse, and rat cell lysates or serum samples. The assay provides quantitative results with excellent reproducibility between experiments, offering efficiency over Western blotting by requiring less sample input, and analysis of up to 40 duplicate samples in just 2.5 hours. The Grp78/BiP ELISA kit is complete, flexible, and put through rigorous fit-for-purpose validation and stability testing to ensure high precision, accuracy, sensitivity, and specificity. It is supplied with an easy-to-follow protocol, precoated microtiter plate, and liquid color-coded reagents.

UNIVERSAL BLOCKING OLIGOS

By incorporating xGen Universal Blocking Oligos into target capture experiments, users can decrease the complexity and increase throughput of their target capture experiment without degradation of performance. Blocking oligos are commonly used to enhance the performance of capture experiments, through the prevention of cross-hybridization between adapter sequences. Adapters ligated to the DNA library before enrichment can hybridize to each other and cause an increase in off-target reads. Blocking oligos bind to these adapters to prevent nonspecific binding. However, when multiple samples are processed simultaneously, each adapter requires a unique blocking oligo, increasing the complexity of the experiment. xGen Universal Blocking Oligos are able to bind to all indexed adapters using a single oligonucleotide sequence, removing the need for multiple oligos. As a result, researchers can more readily multiplex their experiments for cost-effective enrichment of thousands of samples.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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