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Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

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Science  09 May 2014:
Vol. 344, Issue 6184, pp. 649-652
DOI: 10.1126/science.1251152

Article Information

vol. 344 no. 6184 649-652

PubMed: 
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History: 
  • Received for publication January 22, 2014
  • Accepted for publication April 4, 2014

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Author Information

  1. Manisha Sinha1,2,3,4,*,
  2. Young C. Jang1,2,4,*,
  3. Juhyun Oh1,2,4,
  4. Danika Khong1,2,4,
  5. Elizabeth Y. Wu1,2,4,
  6. Rohan Manohar1,2,4,
  7. Christine Miller1,2,4,
  8. Samuel G. Regalado1,5,
  9. Francesco S. Loffredo1,6,
  10. James R. Pancoast1,6,
  11. Michael F. Hirshman2,
  12. Jessica Lebowitz1,2,4,
  13. Jennifer L. Shadrach1,2,3,
  14. Massimiliano Cerletti1,2,,
  15. Mi-Jeong Kim2,
  16. Thomas Serwold2,
  17. Laurie J. Goodyear2,7,
  18. Bernard Rosner8,
  19. Richard T. Lee1,6,
  20. Amy J. Wagers1,2,3,4,
  1. 1Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  2. 2Joslin Diabetes Center, Boston, MA 02215, USA.
  3. 3Howard Hughes Medical Institute, Cambridge, MA, USA.
  4. 4Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA.
  5. 5University of California, Berkeley, CA, USA.
  6. 6Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital and the Brigham Regenerative Medicine Center, Boston, MA, USA.
  7. 7Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
  8. 8Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
  1. Corresponding author. E-mail: amy_wagers{at}harvard.edu
  1. * These authors contributed equally to this work.

  • Present address: UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, London NW3 2QG, UK.

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