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Science  23 May 2014:
Vol. 344, Issue 6186, pp. 923
DOI: 10.1126/science.344.6186.923-a

Cell/Particle Counter

The latest Multisizer 4e Coulter Counter features a new 10 μm aperture that enables users to obtain accurate count, size, and mass distribution for particles and cells ranging from 0.2 μm to 1,600 μm. Digital Pulse Processing provides high-resolution analysis in as many as 400 channels for unparalleled performance in pharmaceutical quality control, bioprocessing, and industrial applications. Incorporating the latest technology and software advances, the Multisizer 4e with unique Digital Pulse Processing delivers dynamic size measurements in real time. High-speed signal digitalization allows the use of various pulse parameters for more accurate cell and particle characterization. Response is unaffected by particle color, shape, composition, or refractive index. Biotech applications include monitoring of transfection; counting mitochondria, organelles, and other intracellular components; and characterizing changes in cell size when changes are made to cultures. In these applications the volumetric analysis of the Multisizer 4e provides a more accurate and informative measurement than measuring size alone.

Imaging Cytometer

The next generation SpectraMax MiniMax 300 Imaging Cytometer enables both cellular visualization and first-of-its-kind stain-free cell-based analysis on the field-upgradable SpectraMax i3 Multi-Mode Microplate Reader.�Brightfield and fluorescence-based green and red channel cellular image acquisition and analysis is made simple using the SoftMax Pro software workflow. Combining cellular imaging with stain-free cell counting and confluency measurements with microplate-based applications, scientists now have more ways to compress their workflows and increase efficiency. The SpectraMax MiniMax 300 Imaging Cytometer now features the patent-pending StainFree Cell Detection algorithm, which enables cell confluency and cell counting measurements on an imaging plate reader without the need for destructive stains, saving researchers valuable time and money. With two additional fluorescence detection channels, green and red, researchers may now perform and analyze a wide range of cellular viability and cell toxicity assays, including ratiometric assays such as transfection efficiency.

Amino Acid Analysis Reagent

The EZ Nin Reagent is a ready-to-use ninhydrin formulation for use in ion exchange chromatography systems with post-column derivatization for improved amino acid analysis. The EZ Nin Reagent has been developed to save laboratory time and waste; it requires no mixing or nitrogen and does not degrade with time or exposure to oxygen, providing reliable analysis over time without loss of sensitivity. Challenges encountered with standard ninhydrin include the long preparation process, instability of the reagent, degradation and waste, and batch-to-batch variability. Each batch of EZ Nin Reagent is identically prepared, enabling the reagent to be topped up on the instrument, eliminating waste or the risk of running out during a series of analyses. EZ Nin Reagent is methanol and hydrindantin free. Biochrom's formulation combines ease of use with unprecedented chemical stability, providing laboratories with the confidence they require when evaluating concentrations of amino acids for diagnosis and monitoring of inborn errors of metabolism.

Aptamer Kits

New aptamer kits are now available for cell isolation and flow cytometry. In addition to their discriminate molecular recognition properties, aptamers offer advantages over antibodies as they can be engineered completely in a test tube, are readily produced by chemical synthesis, possess desirable storage properties, and elicit little or no immunogenicity in therapeutic applications. The AptoPrep cell isolation kit products combine the advantage of the specificity of aptamer to target cell with the convenience of isolation/elution of a particular cell from complex cell samples. The new kits offer unique characteristics and provide advantages over alternative methods. AptoPrep cell isolation kits deliver positive isolation in as little as 30 minutes. Mild and unique cell releasing technology allows users to isolate bead- and aptamer-free cells in as little as one hour. Supplied as a complete kit (biotinylated aptamer, streptavidin magnetic bead, and buffers), AptoPrep cell isolation products deliver unmatched convenience, increased consistency and reliability.

Barcode Cell-Tracking Library

The complex lentiviral-based barcode library allows users to track clonal populations of cells over time or through different treatments. The cell-tracking process begins with the introduction of a packaged lentiviral library encoding a highly heterogeneous population of barcodes into a population of founder cells. After selection, treatment, or differentiation, barcode representation in cells provides data on which clones from founder cells survived, thrived, or died out. The Barcode-Cell Tracking library contains barcodes compatible with the Illumina HiSeq Sequencing platform. For laboratories needing support for this analysis, Cellecta can provide HT Sequencing and Barcode Enumeration of samples. Users provide frozen cell pellets. Cellecta does the rest, including extracting genomic DNA, amplifying the barcodes, performing HT sequenc�ing on the Illumina HiSeq, and enumerating the barcodes from raw sequencing data.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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