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Science  30 May 2014:
Vol. 344, Issue 6187, pp. 1048
DOI: 10.1126/science.344.6187.1048-a

Liquid Chromatography Columns

The new GlycanPac AXR-1 columns help users achieve greater resolution of glycans using HPLC, providing easier profile characterization. This is useful for characterizing glycans from monoclonal antibodies being developed for therapeutics. The columns are designed for excellent resolution of labeled and unlabeled glycans, and are compatible with fluorescence and mass spectrometry detection methods. Mass spectrometry has emerged as a powerful tool for determining the structures of glycans, and this new column is designed to enable researchers to harness the power of high-resolution accurate-mass mass spectrometry at high throughput rates. This column is designed to separate both labeled and native glycans based on the availability of samples. Native glycan separation allows researchers to eliminate the fluorescent labeling step and increase throughput without eroding performance.

Ultralow Flow Electrospray Ionization Instrument

CESI marks a novel combination of capillary electrophoresis and electrospray ionization technologies to create an integrated workflow solution. The CESI-Mass Spectrometry (MS) workflow includes the industry's first commercially available ultralow-flow separation and ESI module for biologics, along with a high-performance, high-resolution, accurate mass instrument. The new CESI 8000 System for Biologics Characterization is an innovative, high-performance separation-electrospray ionization system for mass spectrometry (MS). This new frontend CESI technology can be integrated with the well-established AB Sciex TripleTOF 5600+ mass spectrometry system into a seamless solution. With a single approach that increases efficiency and productivity, the CESI 8000 provides orthogonal and/or superior results compared to dual-method liquid chromatography/mass spectrometry-based approaches. From a single digest and run, users of CESI-MS gain the following: (a) identity and purity information with 100% coverage in a peptide map; (b) heterogeneity information with ultrasensitive glycopeptide quantitation; and (c) stability information identifying, deamidation, cyclization, and oxidation.

Microfluidic UPLC Separation Device

Intended for use with Waters ACQUITY UPLC M-Class System and Xevo TQ-S Mass Spectrometer, the ionKey/MS System physically integrates a UPLC separation into the mass spectrometer producing a significant improvement in sensitivity, enabling unparalleled separation and detection of compounds. With the ionKey/MS, scientists can reduce solvent and sample sizes and no longer have to contend with delicate fittings and columns or concern themselves with extra column dispersion and the inevitable variability and band broadening that comes with it. The iKey Microfluidic Separation Device, which is about the size of a smart phone, contains the fluidic connections, electronics, ESI interface, column heater, eCord Intelligent Chip Technology, and the 1.7 μm UPLC grade particles packed inside a 150 μm I.D. channel to perform hundreds upon hundreds of UPLC separations reproducibly and reliably without a degradation in performance. Additionally, it can be inserted into the source of the mass spectrometer in just a few seconds.

Microfluidic UPLC Separation Device

Intended for use with Waters ACQUITY UPLC M-Class System and Xevo TQ-S Mass Spectrometer, the ionKey/MS System physically integrates a UPLC separation into the mass spectrometer producing a significant improvement in sensitivity, enabling unparalleled separation and detection of compounds. With the ionKey/MS, scientists can reduce solvent and sample sizes and no longer have to contend with delicate fittings and columns or concern themselves with extra column dispersion and the inevitable variability and band broadening that comes with it. The iKey Microfluidic Separation Device, which is about the size of a smart phone, contains the fluidic connections, electronics, ESI interface, column heater, eCord Intelligent Chip Technology, and the 1.7 μm UPLC grade particles packed inside a 150 μm I.D. channel to perform hundreds upon hundreds of UPLC separations reproducibly and reliably without a degradation in performance. Additionally, it can be inserted into the source of the mass spectrometer in just a few seconds.

MALDI-TOF(/TOF)Mass Spectrometers

Autoflex speed, the new member of the Flex series of MALDI-TOF(/TOF) mass spectrometers, delivers superior performance by incorporating numerous innovative technology advancements which provide further enhanced data quality, acquisition speed, class-leading mass and dynamic range, and general robust and efficient performance. The new autoflex speed is designed to dramatically enhance the productivity of laboratories involved in protein sequencing, biomarker discovery, polymer analysis, lipid and glycan analysis, molecular imaging, drug and metabolite tissue distribution, as well as high throughput MALDI Biotyper microbiological molecular identification. System configurations can be optimized for a number of different analytical operations and environments utilizing both TOF and TOF/TOF modes in combination with dedicated hardware and software tools for a variety of applications. The new autoflex speed system incorporates a smartbeam-II laser, now with up to 2 kHz repetition rate with true-pixel image resolution at 20 μm for proteins and has a self-cleaning ion source, which cleans the instrument source in minutes.

Inductively Coupled Plasma Mass Spectrometer

The NexION 350 Inductively Coupled Plasma Mass Spectrometer (ICP-MS) is designed to empower laboratory professionals with greater efficiency in elemental analyses, specifically delivering the most accurate characterization of nanoparticles in the market. Syngistix for ICP-MS Software is a proprietary workflow-based platform with an intuitive interface and new, automated method setup tools for faster, more efficient implementation. The NexION 350 delivers enhanced instrument uptime and productivity through several technical innovations designed to reduce background and interferences, optimize signal stability, and to minimize maintenance requirements and downtime. The combination of these features can enable lab professionals to run more samples per unit of time. The NexION 350's data acquisition rates of 100,000 data points per second (10 times faster than any other ICP-MS currently on the market) are ideal for applications that require fast, transient signal analysis, such as nanoparticle characterization, speciation and laser ablation ensuring that critical events are not missed.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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