Science Webinar Series

The Many Roads to Cell Death: Gaining a Practical Understanding of Apoptosis, Necrosis, and Autophagy

Science  30 May 2014:
Vol. 344, Issue 6187, pp. 1048
DOI: 10.1126/science.344.6187.1048-c

Summary

Cell death is, ironically, an essential part of life. In recent years, the study and understanding of cell death pathways has been dramatically transformed by the insights gained into non-apoptotic pathways, including necro-apoptosis and autophagy, together with a deeper understanding of the mechanism of the apoptotic cascade. New discoveries have been enabled by cutting-edge technologies, particularly in the realm of cytometry and cell-death–specific markers. In this webinar, the latest insights into cell death pathways will be discussed, including the molecular markers and cellular changes that characterize each pathway. Viewers will also learn practical cytometry-based strategies for dissecting cell death pathways, and how to use the data to better understand the pathophysiology of diseases such as cancer as well as to uncover new targets for drug discovery and development.