Aging

Tracking down a tonic for a long life

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Science  30 May 2014:
Vol. 344, Issue 6187, pp. 985
DOI: 10.1126/science.344.6187.985-b

Scientists may not yet have found the fountain of youth, but Ye et al. now report on a screen for drugs that can extend life span in the worm Caenorhabditis elegans. Starting with a collection of over 1200 drugs that have or are suspected to have activity in human cells, they identified nearly 60 compounds that extended life span up to 43%. Many of the compounds targeted proteins that function in signaling pathways between cells, such as hormone or neurotransmitter receptors, particularly those for adrenaline and noradrenaline, serotonin, dopamine, histamine, and serotonin. Given that humans and worms share some aging mechanisms, these results may help bypass the time and expense of similar studies in mammals.

Aging Cell 13, 206 (2014).

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