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Science  06 Jun 2014:
Vol. 344, Issue 6188, pp. 1187
DOI: 10.1126/science.344.6188.1187-a

Gel Imaging Systems

The high sensitivity G:BOX Chemi XX6 and XX9 image analysis systems utilize the power of the latest CCD camera technology. These versatile systems are capable of exceptional imaging of 1-D and 2-D gels, as well as chemi and fluorescent blots. The G:BOX Chemi XX6 and XX9 feature high resolution, high-quantum efficiency (73% quantum efficiency at 425 nm) low noise CCD cameras with the highest level (f0.95) auto-focus lens and six and nine megapixel resolution respectively. Since the cameras are cooled to -53°C, the XX9 and XX6 systems can generate excellent images of chemi blots with minimal background noise and the system's large imaging areas (32.3 cm x 25.6 cm) also mean both systems are ideal for accurately imaging larger blots, as well as larger 1-D and 2-D gels. These systems can be fitted with a range of LED lighting and filter options making them suitable for fluorescence, chemi-luminescence, IR, and 2-D gel applications.

Gel Protein Recovery System

The Gel Protein Recovery GPR-850 instrument delivers efficient recovery of gel separated intact proteins through a multiplexed, automated, microfluidics chip-based process. The GPR System (consisting of the GPR-850 instrument, GPRchips, and GPR Buffers and Reagents) enables researchers to recover intact proteins and peptides for subsequent top-down proteomics experiments. This process facilitates effective protein identification, characterization, and quantitation by mass spectrometry. The effectiveness of the system is enhanced by the use of proprietary reagents together with the microfluidic-based GPRchip. The GPR System combines these components to provide a high throughput recovery platform for researchers interested in studying intact proteins. The GPR system features several kits specifically designed for specialized downstream mass spec applications, including ESI-MS and LC-MALDI. The new GPR-850 instrument features an updated user interface, improved mechanical and industrial design, and comes in six different colors to match the personalities of researchers, laboratories, or institutions.

Gel Image Capture & Documentation System

The new gel documentation and analysis systems omniDOC and omniDOCi provide researchers with a quick, simple, and flexible solution for their gel documentation needs in a compact and affordable benchtop unit. The integral five megapixel camera combined with CSL basic gel analysis software ensures a perfect image every time along with the provision for image analysis. Each omniDOC system provides a simple yet sophisticated imaging solution for most laboratories and most budgets. The five megapixel camera with slide-out ultraviolet transilluminator, optional blue epi-illumination module and white light table, makes the omniDOC suitable for imaging most fluorescent and colormetric gels. The USB port requires a cable to connect the dark room assembly to an external PC for control, while imaging applications are simplified by the pre-focused camera that requires little, or no manual adjustment. The result is easy one-click image acquisition with analysis software guiding the user through every step of the gel documentation process.

Gel Imaging System

The sensitive and robust Amersham Imager 600 series is designed to enable capture and analysis of high-resolution digital images of protein and DNA samples in gels and membranes. These multipurpose imagers deliver high performance imaging to chemiluminescence, fluorescence, and colorimetric applications and the wide dynamic range allows weak and strong signals to be quantitated accurately at the same time. Full system automation means that after startup, there is no need for focusing, insertion of light sources, changing of filters, calibrations, or other adjustments. In each capture mode, images are automatically corrected for both geometric and intensity distortion therefore minimizing the hassle of post-processing for publication. The seamless workflow allows users to readily detect and quantitate bands, determine molecular weight, and perform normalization. With integrated analysis software controllable via a touchscreen device, the results are presented in both tabular and graphical formats, enabling quick and easy generation and analysis of data.

Protein Delivery Reagent

The BioPORTER Protein Delivery Reagent is a unique lipid formulation that allows direct translocation of proteins into living cells. Comprising a unique cationic lipid mixture that interacts non-covalently with the protein, BioPORTER creates a protective vehicle for immediate protein delivery. BioPORTER makes studying protein functionality faster and easier than ever before by bypassing the traditional DNA transfection, transcription, and protein translation processes. After capturing the protein, the reagent transports the lipid protein complex into the target cell. The delivered proteins retain their structure and function while leaving the transduced cells unharmed. Because of its simple delivery mechanism and because there's no fusion partner or covalent bond formation, BioPORTER can efficiently deliver functionally active proteins into a wide range of cell types. The reagent is especially useful when studying protein function in cells that are difficult to transfect using traditional DNA transfection reagents.

Inductively Coupled Plasma Mass Spectrometer

The NexION 350 Inductively Coupled Plasma Mass Spectrometer (ICP-MS) is designed to empower laboratory professionals with greater efficiency in elemental analyses, specifically delivering the most accurate characterization of nanoparticles in the market. Syngistix for ICP-MS Software is a proprietary workflow-based platform with an intuitive interface and new, automated method setup tools for faster, more efficient implementation. The NexION 350 delivers enhanced instrument uptime and productivity through several technical innovations designed to reduce background and interferences, optimize signal stability, and to minimize maintenance requirements and downtime. The combination of these features can enable lab professionals to run more samples per unit of time. The NexION 350's data acquisition rates of 100,000 data points per second (10 times faster than any other ICP-MS currently on the market) are ideal for applications that require fast, transient signal analysis, such as nanoparticle characterization, speciation and laser ablation ensuring that critical events are not missed.

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