Technical Comments

Comment on “Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA”

Science  13 Jun 2014:
Vol. 344, Issue 6189, pp. 1237
DOI: 10.1126/science.1254082

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Abstract

Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.

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