PerspectiveANGIOGENESIS

Targeting vascular sprouts

Science  27 Jun 2014:
Vol. 344, Issue 6191, pp. 1449-1450
DOI: 10.1126/science.1257071

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Summary

Angiogenesis, the formation of new blood vessels, has long been recognized as a hallmark of cancer (1). Its functional importance for the manifestation and progression of tumors has been validated by the therapeutic effects of angiogenesis inhibitors. However, the overall effectiveness of several approved therapies that target the proangiogenic pathways controlled by vascular endothelial growth factor (VEGF) have had rather modest and transient effects in the clinic (2). This is because tumors can activate alternative pathways to adapt to vascular growth restrictions. Emerging evidence (35) indicates that targeting metabolic pathways in blood vessel endothelial cells may be a new and promising strategy because metabolism in these cells not only fuels vascular expansion, but also regulates the very formation of blood vessels.