Arterial Innervation

Netrin-1 helps to get the blood flowing

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Science  04 Jul 2014:
Vol. 345, Issue 6192, pp. 43-44
DOI: 10.1126/science.345.6192.43-c

In moments of crisis, you might remind yourself to breathe, but generally this and other functions controlled by the autonomic sympathetic nervous system, such as swallowing or maintaining blood flow to the heart and central nervous system, proceed without thought. To function properly, the autonomic sympathetic nervous system requires nerves and blood vessels to coordinate with each other as they grow. Using genetic and pharmacological approaches, Brunet et al. find that the protein netrin-1, produced by arteries, directs sympathetic neurons to develop normally around arteries. This parallels netrin-1's role in guiding neuronal axons toward their correct targets.

J. Clin. Invest. 10.1172/JCI75181 (2014).

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