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Worldwide, an estimated 185 million people have been infected with the hepatitis C virus (HCV). Untreated, the infection can lead to cirrhosis, liver failure, and liver cancer, causing up to 500,000 related deaths per year (1, 2), and killing more people than tuberculosis or malaria (3, 4). New treatments are available that can cure over 90% of people with HCV within 12 weeks (5). So what is the problem?