TRANSCRIPTION

TRF2 gets transcription started, too

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Science  25 Jul 2014:
Vol. 345, Issue 6195, pp. 414-415
DOI: 10.1126/science.345.6195.414-c

Transcribing DNA into RNA involves an intricate dance of proteins and nucleic acids. Transcription starts at specific promoter sequences near genes, including one called the TATA box. For most genes, a protein called TBP binds to the TATA box and attracts other proteins required for transcription. Wang et al. studied fruit flies, hoping to learn whether the transcription of genes that encode ribosomal proteins (proteins that help translate RNA to protein), which contain a different promoter (a TCT motif), work in the same way. They found that the TBP-related factor TRF2, rather than TBP, bound to TCT motifs near the transcription start site, and the cell needed TRF2 to transcribe ribosomal proteins.

Genes Dev. 10.1101/gad.245662.114 (2014).

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