Technical Comments

Comment on “Local impermeant anions establish the neuronal chloride concentration”

Science  05 Sep 2014:
Vol. 345, Issue 6201, pp. 1130
DOI: 10.1126/science.1252978

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Abstract

Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, “local impermeant anions establish the neuronal chloride concentration” and thereby determine “the magnitude and direction of GABAAR currents at individual synapses.” If this were possible, perpetual ion-motion machines could be constructed. The authors’ conclusions conflict with basic thermodynamic principles.

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